12/14/2023 0 Comments Statins and grapefruit cyp3a4![]() ![]() Please note this blog should not be taken as a substitute for a medical consultation. Just click on the "add comment" link at the bottom of any of the already published articles and type your request! We'll publish what you requested and will mention that it was you who asked for the article (we'll need your full name for that). Any other visitor could then post a reply to the respective comment and so on (this will definitely make the topic a very interesting one).Įven more, you could simply ask us to publish an article with a topic chosen by yourself. You could easily post your own comments (questions/opinions) about each topic (click on the "add comment" link at the bottom of each article). Our Blog intends to bring to your attention various topics of interest for your health and to keep us connected. psychiatric and neurological medication (Buspirone, Carbamazepine, Sertraline).The action of grapefruit juice on the effect of drugs was discovered by accident in 1989 in an experiment designed to examine the effect of ethanol on the action of felodipine, a calcium channel blocker. benzodiazepines - medicines used to treat anxiety and insomnia (Diazepam, Triazolam, Midazolam, Temazepam) Current medical advice is to avoid grapefruit juice consumption while taking a statin.certain statins (Atorvastatin, Simvastatin, Lovastatin).calcium channel blockers normally used to treat hypertension (Felodipine, Nifedipine).What are the symptoms indicating a statin accumulation in the body? The most relevant of them are: muscular pain, unexplained tiredness and fever.Īpart from the interaction with certain statins, grapefruit could also boost the concentration of other medicines in the organism up to dangerous levels. It is of no importance what time you consume grapefuit as long as you are taking these statins. The fruit and also the juice of grapefruit in its turn destroy this useful enzyme and, as a result certain statins accumulate in growing amounts in the bloodstream eventually causing renal (kidney) and liver failure and ultimately death. CYP3A4 regulates the intestinal absorption of ingested statins into the bloodstream thus preventing this drugs to accumulate in the organism. Some of the enzymes (CYP3A4) commonly present in the intestines are responsible for the breakdown of various medicines such as some of the statins. Grapefruit intake during the treatment with certain cholesterol lowering medication (statins) is a life threatening combination! ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |